Supplementary Figure 4: Replication of behavioral results in a nonclinical sample. | Nature Neuroscience

Supplementary Figure 4: Replication of behavioral results in a nonclinical sample.

From: Adults with autism overestimate the volatility of the sensory environment

Supplementary Figure 4

(a) The same task conducted in a sample of non-clinical volunteers characterised according to high or low autistic traits (AQ) replicates the interaction between expectedness (E=expected, N=neutral, UE=unexpected) and autistic tendency (high AQ, n=26; low AQ, n=31). There was a significant main effect of expectedness (F(2,110)=69.46, P<0.001) and, crucially, a significant expectedness*AQ group interaction (F(2,110)=13.29, P<0.001); suggesting that participants with high AQ scores show a reduced modulation of RT as a function of expectedness (e.g. reduced slope), relative to participants with low AQ scores. There was a main effect of noise (F(2,110)=16.96, P<0.001), and noise*group interaction (F(2,110)=5.07, P=0.008). No other linear interactions or main effects were significant (P’s>0.2). (b) An independent samples t-test demonstrated that behavioural surprise was significantly attenuated in the high AQ group (t(55)=4.32, P<0.001). (c, d) Error rates were subject to the same analysis as above. There was a significant main effect of expectedness (F(2,110)=19.89, P<0.001) but the expectedness*AQ group interaction did not reach significance (F(2,110)=.85, P=0.42); suggesting that the main effect of expectedness on accuracy did not vary as a function of autistic traits. The main effect of noise narrowly missed significance (F(2,110)=2.36, p=0.09), but there was no noise*group interaction (F(2,110)=1.67, P=0.1). One low AQ participant showed relatively high % errors in the UE condition, but their overall errors were within reasonable limits and results are not changed if they are excluded. Compare with Figure 2a-d in the main text. Data points represent individual participants, shaded regions and error bars show 95% confidence intervals and 1 standard deviation of the mean. Star indicates significance at P<0.05

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