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Showing transmitters the door: synucleins accelerate vesicle release

Nature Neuroscience volume 20, pages 629631 (2017) | Download Citation

α-Synuclein is present at high levels in all neurons and their synapses. We now learn that this protein helps dilate the fusion pore, which forms transiently during vesicle exocytosis, promoting release of certain neurotransmitters.

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Author information

Affiliations

  1. Dennis J. Selkoe is at the Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts, USA.

    • Dennis J Selkoe

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  1. Search for Dennis J Selkoe in:

Competing interests

The author is a director of and stockholder in Prothena Biosciences.

Corresponding author

Correspondence to Dennis J Selkoe.

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DOI

https://doi.org/10.1038/nn.4551

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