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Upstream current for a downstream flow

Capillary endothelial cells sense neuronal activity-evoked increases in extracellular K+ via KIR2.1 inwardly rectifying K+ channels. The ensuing hyperpolarization travels upstream along the vascular network, reaching arterioles and evoking vasodilation.

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Figure 1: Upstream endothelial cell conduction of a hyperpolarizing current following increases in neuronal activity.


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Correspondence to Jessica A Filosa.

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Filosa, J. Upstream current for a downstream flow. Nat Neurosci 20, 631–633 (2017).

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