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Upstream current for a downstream flow

Nature Neuroscience volume 20, pages 631–633 (2017)Cite this article

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Capillary endothelial cells sense neuronal activity-evoked increases in extracellular K+ via KIR2.1 inwardly rectifying K+ channels. The ensuing hyperpolarization travels upstream along the vascular network, reaching arterioles and evoking vasodilation.

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Figure 1: Upstream endothelial cell conduction of a hyperpolarizing current following increases in neuronal activity.

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Authors and Affiliations

  1. Jessica A. Filosa is in the Department of Physiology, Augusta University, Augusta, Georgia, USA.,

    Jessica A Filosa

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  1. Jessica A Filosa
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Correspondence to Jessica A Filosa.

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The author declares no competing financial interests.

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Filosa, J. Upstream current for a downstream flow. Nat Neurosci 20, 631–633 (2017). https://doi.org/10.1038/nn.4542

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