Cocaine, cadherins and synaptic plasticity

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Addictive substances hijack the reward system partly via synaptic plasticity onto dopamine neurons. Cadherins may contribute to cocaine-evoked adaptations, supporting the notion that drug addiction is a synaptic disease.

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Figure 1: Cadherins and synaptic plasticity.

Marina Corral Spence/ Springer Nature

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Correspondence to Manuel Mameli.

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The authors declare no competing financial interests.

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Valentinova, K., Mameli, M. Cocaine, cadherins and synaptic plasticity. Nat Neurosci 20, 499–501 (2017) doi:10.1038/nn.4535

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