Addictive substances hijack the reward system partly via synaptic plasticity onto dopamine neurons. Cadherins may contribute to cocaine-evoked adaptations, supporting the notion that drug addiction is a synaptic disease.
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Valentinova, K., Mameli, M. Cocaine, cadherins and synaptic plasticity. Nat Neurosci 20, 499–501 (2017). https://doi.org/10.1038/nn.4535
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DOI: https://doi.org/10.1038/nn.4535
