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Summing up the parts of the hypothalamus

Nature Neuroscience volume 20, pages 378–379 (2017)Cite this article

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A catalog of the cells found in the hypothalamic arcuate–median eminence complex provides insights into genome-wide association studies of complex traits

With billions of cells, the mammalian brain provides a monumental challenge to the reductionist approach. However, recent technological advances have made it possible to acquire quantitative genome-wide measurements of the transcriptome from single cells (scRNA-seq)1. Thus, it is now possible to create a detailed catalog of the different cells and molecules present in a specific tissue or brain region. With a cellular catalog in hand, the next challenge will be to understand how the different components interact and how complex phenotypes emerge.

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Figure 1: Combining GWAS and scRNA-seq can provide new insights regarding the genetic and cellular basis of traits and diseases.

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  1. Martin Hemberg is at the Wellcome Trust Sanger Institute, Hinxton, UK.,

    Martin Hemberg

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  1. Martin Hemberg
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Correspondence to Martin Hemberg.

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The author declares no competing financial interests.

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Hemberg, M. Summing up the parts of the hypothalamus. Nat Neurosci 20, 378–379 (2017). https://doi.org/10.1038/nn.4515

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