Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Commentary
  • Published:

On being a circuit psychiatrist

Abstract

At this unique and exciting time for psychiatry, novel therapies for individuals with mental illnesses seem just around the corner. In particular, recent technological advancements in the study of neural circuits provide reasons to be optimistic that the field is headed in the right direction. Nonetheless, maximizing the chances of translating these advancements into real improvements in patient care requires a carefully considered road map.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. LeDoux, J. Curr. Biol. 17, R868–R874 (2007).

    Article  CAS  Google Scholar 

  2. Fanselow, M.S. & Gale, G.D. Ann. NY Acad. Sci. 985, 125–134 (2003).

    Article  Google Scholar 

  3. Davis, M. Int. Rev. Neurobiol. 36, 225–266 (1994).

    Article  CAS  Google Scholar 

  4. Morrison, S.E. & Salzman, C.D. Curr. Opin. Neurobiol. 20, 221–230 (2010).

    Article  CAS  Google Scholar 

  5. Gallagher, M. & Schoenbaum, G. Ann. NY Acad. Sci. 877, 397–411 (1999).

    Article  CAS  Google Scholar 

  6. Paton, J.J., Belova, M.A., Morrison, S.E. & Salzman, C.D. Nature 439, 865–870 (2006).

    Article  CAS  Google Scholar 

  7. Namburi, P. et al. Nature 520, 675–678 (2015).

    Article  CAS  Google Scholar 

  8. Beyeler, A. et al. Neuron 90, 348–361 (2016).

    Article  CAS  Google Scholar 

  9. Gore, F. et al. Cell 162, 134–145 (2015).

    Article  CAS  Google Scholar 

  10. Miller, G. Science 314, 1674–1676 (2006).

    Article  CAS  Google Scholar 

  11. Rakoczy, E.P. et al. Lancet 386, 2395–2403 (2015).

    Article  CAS  Google Scholar 

  12. Kelly, M.J., O'Keeffe, G.W. & Sullivan, A.M. Expert Rev. Mol. Med. 17, e8 (2015).

    Article  Google Scholar 

  13. Pleticha, J., Maus, T.P. & Beutler, A.S. Mayo Clin. Proc. 91, 522–533 (2016).

    Article  Google Scholar 

  14. Jennings, C.G. et al. Nat. Neurosci. 19, 1123–1130 (2016).

    Article  Google Scholar 

  15. Spellman, T. et al. Nature 522, 309–314 (2015).

    Article  CAS  Google Scholar 

  16. Tamura, M., Mukai, J., Gordon, J.A. & Gogos, J.A. Neuron 89, 1100–1109 (2016).

    Article  CAS  Google Scholar 

  17. Wells, M.F., Wimmer, R.D., Schmitt, L.I., Feng, G. & Halassa, M.M. Nature 532, 58–63 (2016).

    Article  CAS  Google Scholar 

  18. Lozano, A.M. & Lipsman, N. Neuron 77, 406–424 (2013).

    Article  CAS  Google Scholar 

  19. Chervyakov, A.V., Chernyavsky, A.Y., Sinitsyn, D.O. & Piradov, M.A. Front. Hum. Neurosci. 9, 303 (2015).

    Article  Google Scholar 

  20. Sullivan, P.F., Daly, M.J. & O'Donovan, M. Nat. Rev. Genet. 13, 537–551 (2012).

    Article  CAS  Google Scholar 

  21. Estes, M.L. & McAllister, A.K. Science 353, 772–777 (2016).

    Article  CAS  Google Scholar 

  22. Nemeroff, C.B. Neuron 89, 892–909 (2016).

    Article  CAS  Google Scholar 

  23. Heckenast, J.R., Wilkinson, L.S. & Jones, M.W. Adv. Genet. 92, 75–106 (2015).

    Article  CAS  Google Scholar 

  24. Glasser, M.F. et al. Nat. Neurosci. 19, 1175–1187 (2016).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Joshua A Gordon.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Gordon, J. On being a circuit psychiatrist. Nat Neurosci 19, 1385–1386 (2016). https://doi.org/10.1038/nn.4419

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nn.4419

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing