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Life and death rest on a bivalent chromatin state

Neurons require lifelong maintenance of their transcriptional program, which includes stable expression of cell-type-specific identity genes. A study now shows that PRC2-mediated chromatin repression in adulthood is critical for the maintenance of neuronal identity gene expression and neuronal survival.

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Figure 1: The PRC2 complex includes histone H3K27 methyltransferase Ezh1 or Ezh2, along with several other protein subunits3.


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Correspondence to X William Yang.

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Yang, X. Life and death rest on a bivalent chromatin state. Nat Neurosci 19, 1271–1273 (2016).

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