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Treatment synergy in axon regeneration

Injured mouse retinal ganglion cells, upon a combination of treatments, can regrow their axons along the entire optic pathway and re-establish connections with their correct brain targets. This can partially restore function.

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Figure 1: Combinatorial treatment drives retinal ganglion cell (RGC) axons regrowth and reconnection with their correct brain targets.


  1. He, Z. & Jin, Y. Neuron 90, 437–451 (2016).

    Article  CAS  Google Scholar 

  2. Shum, J.W., Liu, K. & So, K.F. Neural Regen. Res. 11, 32–36 (2016).

    Article  Google Scholar 

  3. Lim, J.-H.A. et al. Nat. Neurosci. 19, 1073–1084 (2016).

    Article  CAS  Google Scholar 

  4. Park, K.K. et al. Science 322, 963–966 (2008).

    Article  CAS  Google Scholar 

  5. Smith, P.D. et al. Neuron 64, 617–623 (2009).

    Article  CAS  Google Scholar 

  6. Sun, F. et al. Nature 480, 372–375 (2011).

    Article  CAS  Google Scholar 

  7. de Lima, S. et al. Proc. Natl. Acad. Sci. USA 109, 9149–9154 (2012).

    Article  CAS  Google Scholar 

  8. Duan, X. et al. Neuron 85, 1244–1256 (2015).

    Article  CAS  Google Scholar 

  9. Bei, F. et al. Cell 164, 219–232 (2016).

    Article  CAS  Google Scholar 

  10. Li, S. et al. Proc. Natl. Acad. Sci. USA 113, 1937–1942 (2016).

    Article  CAS  Google Scholar 

  11. Goldberg, J.L. et al. Neuron 33, 689–702 (2002).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Jacek Krol or Botond Roska.

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The authors declare no competing financial interests.

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Krol, J., Roska, B. Treatment synergy in axon regeneration. Nat Neurosci 19, 983–984 (2016).

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