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Bidirectional prefrontal-hippocampal interactions support context-guided memory

Nature Neuroscience volume 19, pages 992994 (2016) | Download Citation

Abstract

We compared the dynamics of hippocampal and prefrontal interactions in rats as they used spatial contexts to guide the retrieval of object memories. Functional connectivity analysis indicated a flow of contextual information from the hippocampus to prefrontal cortex upon the rat's entry into the spatial context. Conversely, upon the onset of object sampling, the direction of information flow reversed, consistent with prefrontal control over the retrieval of context-appropriate hippocampal memory representations.

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Acknowledgements

The work was supported by NIMH grants MH 094263 and MH 051570 to H.E.

Author information

Affiliations

  1. Center for Memory and Brain, Boston University, Boston, Massachusetts, USA.

    • Ryan Place
    • , Anja Farovik
    • , Marco Brockmann
    •  & Howard Eichenbaum

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Contributions

All authors designed the experiment. R.P., A.F. and M.B. conducted the experiment. R.P. conduced the data analyses. R.P. and H.E. wrote the paper.

Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Howard Eichenbaum.

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DOI

https://doi.org/10.1038/nn.4327

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