Rare genetic variants and schizophrenia

A study reports mutations in a histone methyltransferase gene, SETD1A, in schizophrenia patients and demonstrates that tens of thousands of people must be screened to provide robust evidence of a gene's involvement in schizophrenia.

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Figure 1: The path from exome analysis to gene finding in schizophrenia.

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Correspondence to Jonathan Flint.

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Flint, J. Rare genetic variants and schizophrenia. Nat Neurosci 19, 525–527 (2016). https://doi.org/10.1038/nn.4271

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