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Hippogate: a break-in from entorhinal cortex

Discrimination of neutral from harmful environments is important for survival. But how do salient contextual signals yield persisting memories? A study uncovers a circuit that increases the specificity of hippocampus-based memories.

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Figure 1: Functional organization of the LEC-hippocampus circuit.

Katie Vicari/Nature Publishing Group

References

  1. Basu, J. et al. Science published online, doi:10.1126/science.aaa5694 (8 January 2016).

  2. Deshmukh, S.S. & Knierim, J.J. Front. Behav. Neurosci. 5, 69 (2011).

    Article  Google Scholar 

  3. Melzer, S. et al. Science 335, 1506–1510 (2012).

    Article  CAS  Google Scholar 

  4. Cope, D.W. et al. Neuroscience 109, 63–80 (2002).

    Article  CAS  Google Scholar 

  5. Basu, J. et al. Neuron 79, 1208–1221 (2013).

    Article  CAS  Google Scholar 

  6. Dudman, J.T., Tsay, D. & Siegelbaum, S.A. Neuron 56, 866–879 (2007).

    Article  CAS  Google Scholar 

  7. Xu, J.-Y., Zhang, J. & Chen, C. J. Physiol. (Lond.) 590, 2305–2315 (2012).

    Article  CAS  Google Scholar 

  8. Fanselow, M.S. & Dong, H.-W. Neuron 65, 7–19 (2010).

    Article  CAS  Google Scholar 

  9. Lee, S.H. et al. Neuron 82, 1129–1144 (2014).

    Article  CAS  Google Scholar 

  10. Maroso, M. et al. Neuron (in the press).

  11. Yeckel, M.F. & Berger, T.W. Proc. Natl. Acad. Sci. USA 87, 5832–5836 (1990).

    Article  CAS  Google Scholar 

  12. Igarashi, K.M., Lu, L., Colgin, L.L., Moser, M.-B. & Moser, E.I. Nature 510, 143–147 (2014).

    Article  CAS  Google Scholar 

  13. Sanders, H., Rennó-Costa, C., Idiart, M. & Lisman, J. Trends Neurosci. 38, 763–775 (2015).

    Article  CAS  Google Scholar 

  14. Bittner, K.C. et al. Nat. Neurosci. 18, 1133–1142 (2015).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Allyson Alexander or Ivan Soltesz.

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Alexander, A., Soltesz, I. Hippogate: a break-in from entorhinal cortex. Nat Neurosci 19, 530–532 (2016). https://doi.org/10.1038/nn.4253

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