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Targeting PTEN interactions for Alzheimer's disease

Nature Neuroscience volume 19, pages 416418 (2016) | Download Citation

Depression of AMPA receptor–mediated synaptic currents and impairment of long-term potentiation, triggered by amyloid-β, are the hallmarks of Alzheimer's pathophysiology. These dysfunctions are now linked to upregulated PDZ domain–dependent PTEN translocation to spines, contributing to cognitive deficits in model mice.

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Author information

Affiliations

  1. Samuel Frere and Inna Slutsky are in the Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

    • Samuel Frere
    •  & Inna Slutsky
  2. Inna Slutsky is at the Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.

    • Inna Slutsky

Authors

  1. Search for Samuel Frere in:

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Competing interests

The authors declare no competing financial interests.

Corresponding authors

Correspondence to Samuel Frere or Inna Slutsky.

About this article

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DOI

https://doi.org/10.1038/nn.4248

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