Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Illuminating next-generation brain therapies

A clinical trial inspired and guided by optogenetics experiments in rodents reports the outcome of targeted transcranial magnetic stimulation in patients suffering from cocaine addiction.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: A clinical trial for patients with cocaine addiction guided by rodent optogenetics.


  1. Office of National Drug Control Policy. The Economic Costs of Drug Abuse in the United States, 1992–2002. Publication No. 207303 (Washington, DC: Executive Office of the President, 2004).

  2. Deisseroth, K. Nat. Neurosci. 18, 1213–1225 (2015).

    Article  CAS  Google Scholar 

  3. Goshen, I. et al. Cell 147, 678–689 (2011).

    Article  CAS  Google Scholar 

  4. Yizhar, O. et al. Nature 477, 171–178 (2011).

    Article  CAS  Google Scholar 

  5. Berndt, A. et al. Proc. Natl. Acad. Sci. USA published online, doi:10.1073/pnas.1523341113 (22 December 2015).

  6. Terraneo, A. et al. Eur. Neuropsychopharmacol. published online, doi:10.1016/j.euroneuro.2015.11.011 (20 November 2015).

  7. Chen, B.T. et al. Nature 496, 359–362 (2013).

    Article  CAS  Google Scholar 

  8. George, M.S., Taylor, J.J. & Short, E.B. Curr. Opin. Psychiatry 26, 13–18 (2013).

    Article  Google Scholar 

  9. Ferenczi, E. A. et al. Science doi:10.1126/science.aac9698 (1 January 2016).

  10. Substance Abuse and Mental Health Services Administration. Results from the 2013 National Survey on Drug Use and Health: Summary of National Findings, NSDUH Series H-48, HHS Publication No. (SMA) 14–4863 (Rockville, MD: Substance Abuse and Mental Health Services Administration, 2014).

  11. Gradinaru, V., Mogri, M., Thompson, K.R., Henderson, J.M. & Deisseroth, K. Science 324, 354–359 (2009).

    Article  CAS  Google Scholar 

  12. Deisseroth, K. Nature 505, 309–317 (2014).

    Article  CAS  Google Scholar 

  13. Whitmer, D. et al. Front. Hum. Neurosci. 6, 155 (2012).

    Article  Google Scholar 

  14. Riva-Posse, P. et al. Biol. Psychiatry 76, 963–969 (2014).

    Article  Google Scholar 

  15. Creed, M., Pascoli, V.J. & Lüscher, C. Science 347, 659–664 (2015).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Karl Deisseroth.

Ethics declarations

Competing interests

K.D. is a consultant and shareholder of Circuit Therapeutics Inc., a start-up company building platforms for drug discovery and nervous system intervention with optogenetics.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Ferenczi, E., Deisseroth, K. Illuminating next-generation brain therapies. Nat Neurosci 19, 414–416 (2016).

Download citation

  • Published:

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing