(a) Upregulation of Tyrobp mRNA in the dorsal horn persists 7 d post-nerve injury (n = 3 mice/group). (b) CSF1 induction is preserved in injured (ATF3+) sensory neurons of Tyrobp–/– mice (1 d post injury). Scale bar represents 50 μm. Tyrobp–/– mice have normal Rotarod motor activity (c), normal responses to noxious heat in the Hargreaves (d) and hot plate tests (e). N = 6 mice/group (c-e). Data are presented as mean ± s.e.m. ***p≤0.001.