Supplementary Figure 4: Csf1 deletion from sensory neurons prevents nerve injury-induced mechanical hypersensitivity for at least 4 weeks. | Nature Neuroscience

Supplementary Figure 4: Csf1 deletion from sensory neurons prevents nerve injury-induced mechanical hypersensitivity for at least 4 weeks.

From: Injured sensory neuron–derived CSF1 induces microglial proliferation and DAP12-dependent pain

Supplementary Figure 4

(a) Mice with Advillin-Cre-mediated deletion of Csf1 from sensory neurons do not develop mechanical hypersensitivity for at least 4 weeks after nerve injury (n = 4–5 mice/group). These mutant mice have normal body weight (n = 7 mice/group) (b), normal Rotarod motor function (n = 7 mice/group) (c), normal behavioral responses to noxious heat (n = 7 and 6 mice/group) (d,e), normal nocifensive behavior in an inflammatory pain (hindpaw formalin) model (n = 6 mice/group) (f), and normal numbers of CGRP- and NF200-expressing DRG neurons (n = 3 mice/group) (g,h). In the box plots, the box limits show the first and third quartile, the center line is the median and the whiskers represent the minimum and maximum values. Other data are presented as mean ± s.e.m. *** p≤0.001, **** p≤0.0001.

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