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From phenotypic chaos to neurobiological order

Complex demographic and behavioral phenotypes can arise from coordinated interactions among brain systems. A single axis of co-variation spanning 'negative' and 'positive' attributes links diverse participant characteristics with specific patterns of brain connectivity.

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Figure 1: A single positive-negative mode of covariation links diverse demographic and behavioral phenotypes with the collective set of functional connections in the human brain.

References

  1. 1

    Houle, D., Govindaraju, D.R. & Omholt, S. Nat. Rev. Genet. 11, 855–866 (2010).

    CAS  Article  Google Scholar 

  2. 2

    Smith, S.M. et al. Nat. Neurosci. 18, 1565–1567 (2015).

    CAS  Article  Google Scholar 

  3. 3

    Zuo, X.-N. et al. Sci. Data 1, 140049 (2014).

    CAS  Article  Google Scholar 

  4. 4

    Biswal, B.B. et al. Proc. Natl. Acad. Sci. USA 107, 4734–4739 (2010).

    CAS  Article  Google Scholar 

  5. 5

    Van Essen, D.C. et al. Neuroimage 80, 62–79 (2013).

    Article  Google Scholar 

  6. 6

    Holmes, A.J. et al. Sci. Data 2, 150031 (2015).

    Article  Google Scholar 

  7. 7

    Thompson, P.M. et al. Brain Imaging Behav. 8, 153–182 (2014).

    PubMed  PubMed Central  Google Scholar 

  8. 8

    Fox, P.T., Lancaster, J.L., Laird, A.R. & Eickhoff, S.B. Annu. Rev. Neurosci. 37, 409–434 (2014).

    CAS  Article  Google Scholar 

  9. 9

    Crossley, N.A. et al. Proc. Natl. Acad. Sci. USA 110, 11583–11588 (2013).

    CAS  Article  Google Scholar 

  10. 10

    Yeo, B.T.T. et al. Cereb. Cortex 25, 3654–3672 (2015).

    Article  Google Scholar 

  11. 11

    Spearman, C. Am. J. Psychol. 15, 201–292 (1904).

    Article  Google Scholar 

  12. 12

    Buckner, R.L., Andrews-Hanna, J.R. & Schacter, D.L. Ann. NY Acad. Sci. 1124, 1–38 (2008).

    Article  Google Scholar 

  13. 13

    Hampshire, A., Highfield, R.R., Parkin, B.L. & Owen, A.M. Neuron 76, 1225–1237 (2012).

    CAS  Article  Google Scholar 

  14. 14

    Buckner, R.L., Krienen, F.M. & Yeo, B.T.T. Nat. Neurosci. 16, 832–837 (2013).

    Article  Google Scholar 

  15. 15

    Yeo, B.T.T. et al. J. Neurophysiol. 106, 1125–1165 (2011).

    Article  Google Scholar 

Download references

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Correspondence to Avram J Holmes or B T Thomas Yeo.

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Holmes, A., Yeo, B. From phenotypic chaos to neurobiological order. Nat Neurosci 18, 1532–1534 (2015). https://doi.org/10.1038/nn.4145

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