From phenotypic chaos to neurobiological order

Nature Neuroscience volume 18, pages1532–1534(2015)Cite this article

Subjects

Complex demographic and behavioral phenotypes can arise from coordinated interactions among brain systems. A single axis of co-variation spanning 'negative' and 'positive' attributes links diverse participant characteristics with specific patterns of brain connectivity.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

Rent or Buy

All prices are NET prices.

Figure 1: A single positive-negative mode of covariation links diverse demographic and behavioral phenotypes with the collective set of functional connections in the human brain.

References

  1. 1

    Houle, D., Govindaraju, D.R. & Omholt, S. Nat. Rev. Genet. 11, 855–866 (2010).

  2. 2

    Smith, S.M. et al. Nat. Neurosci. 18, 1565–1567 (2015).

  3. 3

    Zuo, X.-N. et al. Sci. Data 1, 140049 (2014).

  4. 4

    Biswal, B.B. et al. Proc. Natl. Acad. Sci. USA 107, 4734–4739 (2010).

  5. 5

    Van Essen, D.C. et al. Neuroimage 80, 62–79 (2013).

  6. 6

    Holmes, A.J. et al. Sci. Data 2, 150031 (2015).

  7. 7

    Thompson, P.M. et al. Brain Imaging Behav. 8, 153–182 (2014).

  8. 8

    Fox, P.T., Lancaster, J.L., Laird, A.R. & Eickhoff, S.B. Annu. Rev. Neurosci. 37, 409–434 (2014).

  9. 9

    Crossley, N.A. et al. Proc. Natl. Acad. Sci. USA 110, 11583–11588 (2013).

  10. 10

    Yeo, B.T.T. et al. Cereb. Cortex 25, 3654–3672 (2015).

  11. 11

    Spearman, C. Am. J. Psychol. 15, 201–292 (1904).

  12. 12

    Buckner, R.L., Andrews-Hanna, J.R. & Schacter, D.L. Ann. NY Acad. Sci. 1124, 1–38 (2008).

  13. 13

    Hampshire, A., Highfield, R.R., Parkin, B.L. & Owen, A.M. Neuron 76, 1225–1237 (2012).

  14. 14

    Buckner, R.L., Krienen, F.M. & Yeo, B.T.T. Nat. Neurosci. 16, 832–837 (2013).

  15. 15

    Yeo, B.T.T. et al. J. Neurophysiol. 106, 1125–1165 (2011).

Download references

Author information

Affiliations

  1. Avram J. Holmes is at the Department of Psychology, Yale University, New Haven, Connecticut, USA
    • Avram J Holmes
  2. B.T. Thomas Yeo is at the Department of Electrical & Computer Engineering, Clinical Imaging Research Centre, Singapore Institute for Neurotechnology and Memory Networks Programme, National University of Singapore, Singapore.
    • B T Thomas Yeo
Authors
  1. Avram J Holmes
    View author publications
    You can also search for this author in
  2. B T Thomas Yeo
    View author publications
    You can also search for this author in

Corresponding authors

Correspondence to Avram J Holmes or B T Thomas Yeo.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Holmes, A., Yeo, B. From phenotypic chaos to neurobiological order. Nat Neurosci 18, 1532–1534 (2015). https://doi.org/10.1038/nn.4145

Download citation

Further reading