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The changing tree in Parkinson's disease

Nature Neuroscience volume 18, pages 1196–1198 (2015)Cite this article

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Dopamine loss in Parkinson's disease affects not only the basal ganglia, but also motor cortex, causing a surprising increase of spine turnover in the cortical dendritic tree and altering synaptic plasticity and memory retention.

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Figure 1: Effects of dopaminergic denervation on the motor cortex.

Kim Caesar/Nature Publishing Group

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Authors and Affiliations

  1. Dipartimento di Medicina, Paolo Calabresi and Massimiliano Di Filippo are at the Clinica Neurologica, Università degli Studi di Perugia, Ospedale Santa Maria della Misericordia, Perugia, Italy,

    Paolo Calabresi & Massimiliano Di Filippo

  2. Paolo Calabresi is at the IRCCS Fondazione Santa Lucia, Rome, Italy.,

    Paolo Calabresi

Authors
  1. Paolo Calabresi
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  2. Massimiliano Di Filippo
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Correspondence to Paolo Calabresi.

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The authors declare no competing financial interests.

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Calabresi, P., Di Filippo, M. The changing tree in Parkinson's disease. Nat Neurosci 18, 1196–1198 (2015). https://doi.org/10.1038/nn.4092

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