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The changing tree in Parkinson's disease

Dopamine loss in Parkinson's disease affects not only the basal ganglia, but also motor cortex, causing a surprising increase of spine turnover in the cortical dendritic tree and altering synaptic plasticity and memory retention.

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Figure 1: Effects of dopaminergic denervation on the motor cortex.

Kim Caesar/Nature Publishing Group


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Correspondence to Paolo Calabresi.

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Calabresi, P., Di Filippo, M. The changing tree in Parkinson's disease. Nat Neurosci 18, 1196–1198 (2015).

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