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The binding solution?

How do neurons combine distinct information streams and form long-lasting associations? Dendritic plateau potentials may allow the integration and storage of coincident location and contextual information in hippocampal neurons.

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Figure 1: Place fields are likely formed and amplified by dendritic plateau potentials.


  1. 1

    Hameroff, S.R., Craddock, T.J. & Tuszynski, J.A. J. Integr. Neurosci. 13, 229–252 (2014).

    Article  Google Scholar 

  2. 2

    Merker, B. Neurosci. Biobehav. Rev. 37, 401–417 (2013).

    Article  Google Scholar 

  3. 3

    Riesenhuber, M. & Poggio, T. Neuron 24, 87–93, 111–125 (1999).

    CAS  Article  Google Scholar 

  4. 4

    Watanabe, M., Nakanishi, O. & Aihara, K. Neural Netw. 14, 395–406 (2001).

    CAS  Article  Google Scholar 

  5. 5

    Sheffield, M.E. & Dombeck, D.A. Nature 517, 200–204 (2015).

    CAS  Article  Google Scholar 

  6. 6

    Cichon, J. & Gan, W.B. Nature 520, 180–185 (2015).

    CAS  Article  Google Scholar 

  7. 7

    Magee, J.C. & Johnston, D. Science 275, 209–213 (1997).

    CAS  Article  Google Scholar 

  8. 8

    Bittner, K. et al. Nat. Neurosci. 18, 1133–1142 (2015).

    CAS  Article  Google Scholar 

  9. 9

    Wood, E.R., Dudchenko, P.A., Robitsek, R.J. & Eichenbaum, H. Neuron 27, 623–633 (2000).

    CAS  Article  Google Scholar 

  10. 10

    Takahashi, H. & Magee, J.C. Neuron 62, 102–111 (2009).

    CAS  Article  Google Scholar 

  11. 11

    Larkum, M. Trends Neurosci. 36, 141–151 (2013).

    CAS  Article  Google Scholar 

  12. 12

    Harvey, C.D., Collman, F., Dombeck, D.A. & Tank, D.W. Nature 461, 941–946 (2009).

    CAS  Article  Google Scholar 

  13. 13

    Mizuseki, K., Sirota, A., Pastalkova, E. & Buzsaki, G. Neuron 64, 267–280 (2009).

    CAS  Article  Google Scholar 

  14. 14

    Xu, N.L. et al. Nature 492, 247–251 (2012).

    CAS  Article  Google Scholar 

Download references

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Correspondence to Daniel A Dombeck.

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Sheffield, M., Dombeck, D. The binding solution?. Nat Neurosci 18, 1060–1062 (2015).

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