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Removing synaptic brakes on learning

Imaging experiments in awake mice reveal striking, circuit-specific synaptic structural remodeling of inhibitory axons during learning.

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Figure 1: Schematic of an excitatory layer 2/3 pyramidal neuron (black) contacted by a somatostatin interneuron (SOM-IN, red) on its apical dendrites and a parvalbumin interneuron (PV-IN, blue) on its perisomatic dendrites.

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Correspondence to Vincenzo De Paola.

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Grillo, F., West, L. & De Paola, V. Removing synaptic brakes on learning. Nat Neurosci 18, 1062–1064 (2015). https://doi.org/10.1038/nn.4073

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