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Coding the direct/indirect pathways by D1 and D2 receptors is not valid for accumbens projections

Nature Neuroscience volume 18, pages 12301232 (2015) | Download Citation

Abstract

It is widely accepted that D1 dopamine receptor–expressing striatal neurons convey their information directly to the output nuclei of the basal ganglia, whereas D2-expressing neurons do so indirectly via pallidal neurons. Combining optogenetics and electrophysiology, we found that this architecture does not apply to mouse nucleus accumbens projections to the ventral pallidum. Thus, current thinking attributing D1 and D2 selectivity to accumbens projections akin to dorsal striatal pathways needs to be reconsidered.

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Acknowledgements

We thank T.C. Jhou and R.J. Smith for their assistance with the histology experiments. We thank E.J. Nestler (Mount Sinai School of Medicine) for providing D1-Cre and D2-Cre breeding pairs, and R. Gregory and J. Hyang for genotyping the mice. This work was supported by US Public Health Service grants DA03906, DA12513 and DA015369, and a fellowship from the Neuroscience Institute, Medical University of South Carolina.

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Affiliations

  1. Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina, USA.

    • Yonatan M Kupchik
    • , Robyn M Brown
    • , Jasper A Heinsbroek
    • , Danielle J Schwartz
    •  & Peter W Kalivas
  2. Department of Medical Neurobiology, Institute for Medical Research Israel-Canada, The Hebrew University, Jerusalem, Israel.

    • Yonatan M Kupchik
  3. Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Australia.

    • Robyn M Brown
  4. Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, Maryland, USA.

    • Mary Kay Lobo

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Contributions

Y.M.K. and P.W.K. designed the experiments. Y.M.K., R.M.B. and D.J.S. performed microinjection surgeries. J.A.H. and M.K.L. performed double-labeling studies. Y.M.K. performed electrophysiology and histology experiments, and analyzed the data. Y.M.K. and P.W.K. wrote the paper. All of the authors discussed the results and commented on the manuscript.

Competing interests

The authors declare no competing financial interests.

Corresponding authors

Correspondence to Yonatan M Kupchik or Peter W Kalivas.

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DOI

https://doi.org/10.1038/nn.4068

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