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Sex, drugs and pain control

A study finds that pain hypersensitivity in male and female mice is differentially dependent on microglia and T cells, and describes a sex-specific response to microglia-targeted pain treatments. This sex difference will be important to consider when developing treatments for pain and other neurological disorders involving microglia and immune cells.

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Figure 1: Pain mechanisms differ in male and female mice.

Kim Caesar/Nature Publishing Group


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Correspondence to Mark J Zylka.

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Brings, V., Zylka, M. Sex, drugs and pain control. Nat Neurosci 18, 1059–1060 (2015).

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