A study finds that pain hypersensitivity in male and female mice is differentially dependent on microglia and T cells, and describes a sex-specific response to microglia-targeted pain treatments. This sex difference will be important to consider when developing treatments for pain and other neurological disorders involving microglia and immune cells.
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Brings, V., Zylka, M. Sex, drugs and pain control. Nat Neurosci 18, 1059–1060 (2015). https://doi.org/10.1038/nn.4057
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DOI: https://doi.org/10.1038/nn.4057
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Spinal cord stimulation in chronic pain: evidence and theory for mechanisms of action
Bioelectronic Medicine (2019)