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Genetic variation links creativity to psychiatric disorders

Epidemiological studies and anecdotal evidence show overlap between psychiatric disorders and creativity, but why? A new study uses genome-wide association data from schizophrenia and bipolar disorder to show that genetics are part of the explanation.

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Figure 1: Estimated probability of belonging to national artistic societies or having an artistic profession as a function of genetic risk scores.


  1. 1

    Simeonova, D.I., Chang, K.D., Strong, C. & Ketter, T.A. J. Psychiatr. Res. 39, 623–631 (2005).

    Article  Google Scholar 

  2. 2

    Kyaga, S. et al. Br. J. Psychiatry 199, 373–379 (2011).

    Article  Google Scholar 

  3. 3

    Lauronen, E. et al. Psychiatry 67, 81–98 (2004).

    Article  Google Scholar 

  4. 4

    Power, R.A. et al. Nat. Neurosci. 18, 953–955 (2015).

    CAS  Article  Google Scholar 

  5. 5

    Lee, S.H. et al. Nat. Genet. 45, 984–994 (2013).

    CAS  Article  Google Scholar 

  6. 6

    de Candia, T.R. et al. Am. J. Hum. Genet. 93, 463–470 (2013).

    CAS  Article  Google Scholar 

  7. 7

    Vrieze, S.I., McGue, M. & Iacono, W.G. Hum. Genet. 131, 791–801 (2012).

    Article  Google Scholar 

  8. 8

    Keller, M.C. & Miller, G. Behav. Brain Sci. 29, 385–404, discussion 405–452 (2006).

    Article  Google Scholar 

  9. 9

    Hedrick, P.W. Heredity 82, 126–133 (1999).

    Article  Google Scholar 

  10. 10

    Prout, T. in Evolutionary Genetics From Molecules to Morphology (eds. Singh, R.S. & Krimbas, C.B.) 369–392 (Cambridge University Press, Cambridge, 1999).

    Google Scholar 

Download references

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Correspondence to Matthew C Keller or Peter M Visscher.

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The authors declare no competing financial interests.

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Keller, M., Visscher, P. Genetic variation links creativity to psychiatric disorders. Nat Neurosci 18, 928–929 (2015).

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