MIR137: big impacts from small changes

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Schizophrenia-linked single nucleotide polymorphisms in MIR137 alter expression of miR-137 in neurons. Abnormal expression of miR-137 affects vesicle release at presynaptic terminals and in turn alters hippocampal functioning.

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Figure 1: Enhanced expression of miR-137 restrains release of presynaptic vesicles.

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Correspondence to Fred H Gage.

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The authors declare no competing financial interests.

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Han, J., Sarkar, A. & Gage, F. MIR137: big impacts from small changes. Nat Neurosci 18, 931–933 (2015) doi:10.1038/nn.4045

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