Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

MIR137: big impacts from small changes

Schizophrenia-linked single nucleotide polymorphisms in MIR137 alter expression of miR-137 in neurons. Abnormal expression of miR-137 affects vesicle release at presynaptic terminals and in turn alters hippocampal functioning.

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Figure 1: Enhanced expression of miR-137 restrains release of presynaptic vesicles.

References

  1. Picchioni, M.M. & Murray, R.M. Br. Med. J. 335, 91–95 (2007).

    Article  Google Scholar 

  2. Szatkiewicz, J.P. et al. Mol. Psychiatry 19, 762–773 (2014).

    CAS  Article  Google Scholar 

  3. Schizophrenia Working Group of the Psychiatric Genomics Consortium. Nature 511, 421–427 (2014).

  4. Siegert, S. et al. Nat. Neurosci. 18, 1008–1016 (2015).

    CAS  Article  Google Scholar 

  5. Ripke, S. et al. Nat. Genet. 43, 969–976 (2011).

    CAS  Article  Google Scholar 

  6. Guella, I. et al. J. Psychiatr. Res. 47, 1215–1221 (2013).

    Article  Google Scholar 

  7. Strazisar, M. et al. Mol. Psychiatry 20, 472–481 (2015).

    CAS  Article  Google Scholar 

  8. Erhard, F. et al. Genome Res. 24, 906–919 (2014).

    CAS  Article  Google Scholar 

  9. Bartel, D.P. Cell 136, 215–233 (2009).

    CAS  Article  Google Scholar 

  10. Harrison, P.J. Psychopharmacology (Berl.) 174, 151–162 (2004).

    CAS  Article  Google Scholar 

  11. Kolomeets, N.S., Orlovskaya, D.D. & Uranova, N.A. Synapse 61, 615–621 (2007).

    CAS  Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Fred H Gage.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Han, J., Sarkar, A. & Gage, F. MIR137: big impacts from small changes. Nat Neurosci 18, 931–933 (2015). https://doi.org/10.1038/nn.4045

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nn.4045

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing