Abstract

Postsynaptic remodeling of glutamatergic synapses on ventral striatum (vSTR) medium spiny neurons (MSNs) is critical for shaping stress responses. However, it is unclear which presynaptic inputs are involved. Susceptible mice exhibited increased synaptic strength at intralaminar thalamus (ILT), but not prefrontal cortex (PFC), inputs to vSTR MSNs following chronic social stress. Modulation of ILT-vSTR versus PFC-vSTR neuronal activity differentially regulated dendritic spine plasticity and social avoidance.

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Acknowledgements

This research was supported by US National Institute of Mental Health grants R01 MH090264 (S.J.R.), R01 MH092306 (M.-H.H.), P50 MH096890 (S.J.R. and M.-H.H.), T32 GM089626 (D.J.C.), T32 MH087004 (M.P. and M.H.), F31 MH105217 (M.P.), F32 MH096464 (A.K.F.), P01 DA008227 (R.C.M.) and F30 MH100835 (M.H.).

Author information

Author notes

    • Daniel J Christoffel
    •  & Sam A Golden

    These authors contributed equally to this work.

Affiliations

  1. Fishberg Department of Neuroscience, Friedman Brain Institute Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

    • Daniel J Christoffel
    • , Sam A Golden
    • , Jessica J Walsh
    • , Kevin G Guise
    • , Mitra Heshmati
    • , Aditi Dey
    • , Milo Smith
    • , Nicole Rebusi
    • , Madeline Pfau
    • , Hossein Aleyasin
    • , Lena A Khibnik
    • , Georgia E Hodes
    • , Matthew L Shapiro
    • , Ming-Hu Han
    •  & Scott J Russo
  2. Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California, USA.

    • Daniel J Christoffel
    • , Gabriel A Ben-Dor
    • , Karl Deisseroth
    •  & Robert C Malenka
  3. Department of Pharmacology and Systems Therapeutics, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

    • Jessica J Walsh
    • , Allyson K Friedman
    •  & Ming-Hu Han
  4. Laboratory of Molecular Genetics, Howard Hughes Medical Institute, Rockefeller University, New York, New York, USA.

    • Jessica L Ables
    •  & Ines Ibanez-Tallon
  5. Department of Bioengineering, Stanford University, Stanford, California, USA.

    • Karl Deisseroth

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Contributions

D.J.C., S.A.G. and S.J.R. designed the studies, interpreted the results and wrote the paper. D.J.C., S.A.G., J.J.W., M.H., A.K.F., H.A., L.A.K., N.R., M.P., G.A.B.-D. and G.E.H. performed stereotactic injections, optogenetic experiments and electrophysiology. K.G.G., S.A.G. and M.L.S. performed in vivo ChR2 validation. D.J.C., A.D., J.L.A. and M.S. performed immunohistochemistry. J.L.A. and I.I.-T. generated viruses. K.D., J.J.W., A.K.F., R.C.M. and M.-H.H. provided optogenetics and electrophysiology training. All of the authors edited the paper.

Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Scott J Russo.

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DOI

https://doi.org/10.1038/nn.4034

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