The prefrontal cortex is known to influence dopamine release in the striatum–but how? New data in mice suggest that cortical spine density affects striatal dopamine release via monosynaptic control of dopamine neurons, tracing a chain of events from spine loss to antipsychotic-responsive psychomotor agitation.
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The authors declare no competing financial interests.
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Kellendonk, C., Gordon, J. Once upon a spine: setting striatal dopamine. Nat Neurosci 18, 788–789 (2015). https://doi.org/10.1038/nn.4029