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Once upon a spine: setting striatal dopamine


The prefrontal cortex is known to influence dopamine release in the striatum–but how? New data in mice suggest that cortical spine density affects striatal dopamine release via monosynaptic control of dopamine neurons, tracing a chain of events from spine loss to antipsychotic-responsive psychomotor agitation.

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Figure 1: Kim et al.4 give evidence that a monosynaptic projection from the PFC to dopaminergic neurons in the midbrain regulate dopamine release (left).


  1. Taber, M.T., Das, S. & Fibiger, H.C. J. Neurochem. 65, 1407–1410 (1995).

    Article  CAS  Google Scholar 

  2. Karreman, M. & Moghaddam, B. J. Neurochem. 66, 589–598 (1996).

    Article  CAS  Google Scholar 

  3. Carr, D.B. & Sesack, S.R. J. Neurosci. 20, 3864–3873 (2000).

    Article  CAS  Google Scholar 

  4. Kim, I.H. et al. Nat. Neurosci. 18, 883–891 (2015).

    Article  CAS  Google Scholar 

  5. Turrigiano, G.G. Cell 135, 422–435 (2008).

    Article  CAS  Google Scholar 

  6. Floresco, S.B., West, A.R., Ash, B., Moore, H. & Grace, A.A. Nat. Neurosci. 6, 968–973 (2003).

    Article  CAS  Google Scholar 

  7. Murase, S., Grenhoff, J., Chouvet, G., Gonon, F.G. & Svensson, T.H. Neurosci. Lett. 157, 53–56 (1993).

    Article  CAS  Google Scholar 

  8. Tong, Z.Y., Overton, P.G. & Clark, D. Synapse 22, 195–208 (1996).

    Article  CAS  Google Scholar 

  9. Glausier, J.R. & Lewis, D.A. Neuroscience 251, 90–107 (2013).

    Article  CAS  Google Scholar 

  10. Howes, O.D. et al. Arch. Gen. Psychiatry 69, 776–786 (2012).

    Article  CAS  Google Scholar 

  11. Meyer-Lindenberg, A. et al. Nat. Neurosci. 5, 267–271 (2002).

    Article  CAS  Google Scholar 

  12. Fusar-Poli, P. et al. Mol. Psychiatry 16, 67–75 (2011).

    Article  CAS  Google Scholar 

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Correspondence to Christoph Kellendonk or Joshua A Gordon.

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The authors declare no competing financial interests.

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Kellendonk, C., Gordon, J. Once upon a spine: setting striatal dopamine. Nat Neurosci 18, 788–789 (2015).

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