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Exome sequencing uncovers hidden pathways in familial and sporadic ALS

Amyotrophic lateral sclerosis (ALS) is a complex and as yet untreatable neurodegenerative disorder. We discuss two examples of exome sequencing in large international collections of familial and sporadic ALS cases that are revealing new and potentially treatable pathways, such as those involving autophagy and neuroinflammation.

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Figure 1: Progress of genetic findings related to ALS etiology and pathogenesis.


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Correspondence to Henry Houlden.

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Bettencourt, C., Houlden, H. Exome sequencing uncovers hidden pathways in familial and sporadic ALS. Nat Neurosci 18, 611–613 (2015).

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