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Stem cells: slow and steady wins the race

How are quiescent adult neural stem cells (NSCs) generated during development? A study now identifies a reserve population of p57-expressing, slowly dividing embryonic neural progenitors that later give rise to adult NSCs.

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Figure 1: The embryonic origin of adult NSCs in the SEZ.

Marina Corral Spence/Nature Publishing Group


  1. Kriegstein, A. & Alvarez-Buylla, A. Annu. Rev. Neurosci. 32, 149–184 (2009).

    Article  CAS  Google Scholar 

  2. Encinas, J.M. et al. Cell Stem Cell 8, 566–579 (2011).

    Article  CAS  Google Scholar 

  3. Bonaguidi, M.A. et al. Cell 145, 1142–1155 (2011).

    Article  CAS  Google Scholar 

  4. Kippin, T.E., Martens, D.J. & van der Kooy, D. Genes Dev. 19, 756–767 (2005).

    Article  CAS  Google Scholar 

  5. Furutachi, S., Matsumoto, A., Nakayama, K.I. & Gotoh, Y. EMBO J. 32, 970–981 (2013).

    Article  CAS  Google Scholar 

  6. Calzolari, F. et al. Nat. Neurosci. 18, 490–492 (2015).

    Article  CAS  Google Scholar 

  7. Furutachi, S. et al. Nat. Neurosci. 18, 657–665 (2015).

    Article  CAS  Google Scholar 

  8. Tumbar, T. et al. Science 303, 359–363 (2004).

    Article  CAS  Google Scholar 

  9. Merkle, F.T., Tramontin, A.D., García-Verdugo, J.M. & Alvarez-Buylla, A. Proc. Natl. Acad. Sci. USA 101, 17528–17532 (2004).

    Article  CAS  Google Scholar 

  10. Matsumoto, A. et al. Mol. Cell. Biol. 31, 4176–4192 (2011).

    Article  CAS  Google Scholar 

  11. Bowman, A.N., van Amerongen, R., Palmer, T.D. & Nusse, R. Proc. Natl. Acad. Sci. USA 110, 7324–7329 (2013).

    Article  CAS  Google Scholar 

  12. Taverna, E., Götz, M. & Huttner, W.B. Annu. Rev. Cell Dev. Biol. 30, 465–502 (2014).

    Article  CAS  Google Scholar 

  13. Dehay, C. & Kennedy, H. Nat. Rev. Neurosci. 8, 438–450 (2007).

    Article  CAS  Google Scholar 

  14. Schmechel, D.E. & Rakic, P. Nature 277, 303–305 (1979).

    Article  CAS  Google Scholar 

  15. Dirian, L. et al. Dev. Cell 30, 123–136 (2014).

    Article  CAS  Google Scholar 

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Correspondence to Wieland B Huttner.

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Huttner, W. Stem cells: slow and steady wins the race. Nat Neurosci 18, 613–614 (2015).

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