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Sugar and Alzheimer's disease: a bittersweet truth

Reductions in brain glucose metabolism have long been associated with Alzheimer's disease. A study now demonstrates that the endothelial glucose transporter GLUT1 is vital for maintaining brain energy metabolism and vascular clearance of amyloid-β.

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Figure 1: Mechanisms of brain dysfunction and damage caused by GLUT1 deficiency.


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Correspondence to Costantino Iadecola.

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Iadecola, C. Sugar and Alzheimer's disease: a bittersweet truth. Nat Neurosci 18, 477–478 (2015).

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