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Cocaine shapes chromatin landscapes via Tet1

Chronic cocaine exposure induces long-lasting, transcription-dependent changes in neuronal function. A genome-wide sequencing study shows how cocaine changes the epigenome to exert specific, long-lasting effects on neuronal transcription.

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Figure 1: Cocaine-dependent changes in the architecture of the 5hmC landscape are associated with changes in gene expression.

Marina Corral Spence/Nature Publishing Group

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Correspondence to Anne E West.

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West, A. Cocaine shapes chromatin landscapes via Tet1. Nat Neurosci 18, 478–480 (2015). https://doi.org/10.1038/nn.3985

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