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Explicit memory creation during sleep demonstrates a causal role of place cells in navigation

Nature Neuroscience volume 18, pages 493495 (2015) | Download Citation

Abstract

Hippocampal place cells assemblies are believed to support the cognitive map, and their reactivations during sleep are thought to be involved in spatial memory consolidation. By triggering intracranial rewarding stimulations by place cell spikes during sleep, we induced an explicit memory trace, leading to a goal-directed behavior toward the place field. This demonstrates that place cells' activity during sleep still conveys relevant spatial information and that this activity is functionally significant for navigation.

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Acknowledgements

We thank F.P. Battaglia, M.B. Zugaro, P. Faure, L. Roux, S. Bagur and S.I. Wiener for discussions, and A. Peyrache for discussion and critical readings of an earlier version of the manuscript. Some experiments were done with software developed by G. Cournelle and A. Baelde, engineering students from the ESPCI-ParisTech. This work was supported by the Fondation pour la Recherche Médicale DEQ20120323730, France, by the National Agency for Research ANR-REG-071220-01-01, France, by the CNRS: Programmes Interdisciplinaires de Recherche (Neuro-IC), ATIP-Avenir (2014) and by the city of Paris (Grant Emergence 2014). This work also received support under the program Investissements d'Avenir launched by the French Government and implemented by the ANR, with the references: ANR-10-LABX-54 MEMO LIFE and ANR-11-IDEX-0001-02 PSL* Research University. G.d.L. and M.M.L. were funded by the Ministère de l'Enseignement Supérieur et de la Recherche, France.

Author information

Author notes

    • Gaetan de Lavilléon
    •  & Marie Masako Lacroix

    These authors contributed equally to this work.

    • Laure Rondi-Reig
    •  & Karim Benchenane

    These authors jointly directed this work.

Affiliations

  1. Team Memory, Oscillations and Brain States (MOBs), Brain Plasticity Unit, CNRS UMR 8249, Ecole Supérieure de Physique et de Chimie Industrielles de la Ville de Paris, Paris, France.

    • Gaetan de Lavilléon
    • , Marie Masako Lacroix
    •  & Karim Benchenane
  2. Neuroscience Paris Seine, Cerebellum, Navigation and Memory Team, CNRS UMR 8246; INSERM, UMR-S 1130; Sorbonne Universités, University Pierre and Marie Curie, Paris, France.

    • Gaetan de Lavilléon
    • , Marie Masako Lacroix
    • , Laure Rondi-Reig
    •  & Karim Benchenane

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Contributions

K.B. designed the experiment. G.d.L. and M.M.L. did the experiments. K.B., G.d.L. and M.M.L. analyzed the data. K.B., G.d.L., M.M.L. and L.R.-R. wrote the manuscript.

Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Karim Benchenane.

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DOI

https://doi.org/10.1038/nn.3970

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