News & Views | Published:

ERKquake in Noonan syndrome: one step closer to personalized medicine

Nature Neuroscience volume 17, pages 16271629 (2014) | Download Citation

A study now provides proof of concept that restoration of Ras-Erk signaling during adulthood rescues cellular and cognitive phenotypes in mouse models of the genetic disorder Noonan syndrome.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    & Annu. Rev. Genomics Hum. Genet. 6, 45–68 (2005).

  2. 2.

    , , & Lancet 381, 333–342 (2013).

  3. 3.

    et al. Am. J. Med. Genet. A. 149A, 140–146 (2009).

  4. 4.

    , & Am. J. Med. Genet. A. 161A, 2250–2257 (2013).

  5. 5.

    et al. Nat. Neurosci. 17, 1736–1743 (2014).

  6. 6.

    , & Trends Biochem. Sci. 28, 284–293 (2003).

  7. 7.

    , & Annu. Rev. Neurosci. 27, 279–306 (2004).

  8. 8.

    , & Annu. Rev. Neurosci. 37, 17–38 (2014).

  9. 9.

    & J. Physiol. (Lond.) 232, 331–356 (1973).

  10. 10.

    J. Neurochem. 76, 1–10 (2001).

  11. 11.

    & Neuron 68, 340–361 (2010).

  12. 12.

    et al. Curr. Biol. 15, 1961–1967 (2005).

  13. 13.

    et al. Nature 415, 526–530 (2002).

  14. 14.

    et al. Cell 135, 549–560 (2008).

  15. 15.

    et al. Neurosci. Lett. 515, 28–33 (2012).

Download references

Author information

Affiliations

  1. Mauro Costa-Mattioli is in the Department of Neuroscience and the Memory and Brain Research Center, Baylor College of Medicine, Houston, Texas, USA.

    • Mauro Costa-Mattioli

Authors

  1. Search for Mauro Costa-Mattioli in:

Competing interests

The author declares no competing financial interests.

Corresponding author

Correspondence to Mauro Costa-Mattioli.

About this article

Publication history

Published

DOI

https://doi.org/10.1038/nn.3879

Further reading

Newsletter Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing