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ERKquake in Noonan syndrome: one step closer to personalized medicine

Nature Neuroscience volume 17, pages 1627–1629 (2014)Cite this article

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A study now provides proof of concept that restoration of Ras-Erk signaling during adulthood rescues cellular and cognitive phenotypes in mouse models of the genetic disorder Noonan syndrome.

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Figure 1: Excitation and inhibition imbalance, impaired LTP and long-term memory (LTM) are common features in RASopathies.

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  1. Mauro Costa-Mattioli is in the Department of Neuroscience and the Memory and Brain Research Center, Baylor College of Medicine, Houston, Texas, USA.,

    Mauro Costa-Mattioli

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  1. Mauro Costa-Mattioli
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Correspondence to Mauro Costa-Mattioli.

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Costa-Mattioli, M. ERKquake in Noonan syndrome: one step closer to personalized medicine. Nat Neurosci 17, 1627–1629 (2014). https://doi.org/10.1038/nn.3879

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