Supplementary Figure 6 : Schematic representation of the mechanisms of sodium channel clustering at nodes of Ranvier.

From: A hierarchy of ankyrin-spectrin complexes clusters sodium channels at nodes of Ranvier

Supplementary Figure 6

(a) Cartoons illustrate the substitution of AnkR and βI spectrin results in the compensation for loss of AnkG and βIV spectrin in Avil-Cre; Ank3F/F, and the absence of Na+ channel clustering in AnkG/AnkR-deficient axons despite intact paranodal junctions. (b) Model illustrating the primary and secondary ankyrin/spectrin-dependent clustering mechanisms found at nodes of Ranvier. Higher affinities among nodal proteins are indicated by solid lines, while lower-affinity interactions are indicated by dashed lines.