Supplementary Figure 2 : AnkG-deficient nodes of Ranvier remain intact in aged mice.

From: A hierarchy of ankyrin-spectrin complexes clusters sodium channels at nodes of Ranvier

Supplementary Figure 2

(a,b) Ank3F/F and Avil-Cre; Ank3F/F dorsal roots (a), and Ank3F/F and Six3-Cre; Ank3F/F optic nerve (b) immunostained using antibodies against Na+ channels (red), Caspr (blue), and AnkG (green). Nodes (arrows) of AnkG-deficient axons have Na+ channels. (c,d) Ank3F/F and Avil-Cre; Ank3F/F dorsal roots (c), and Ank3F/F and Six3-Cre; Ank3F/F optic nerve (d) immunostained using antibodies against Na+ channels (red), neurofascin (NF)/Caspr (blue), and AnkR (green). Nodes (arrows) of AnkG-deficient axons have high densities of AnkR colocalized with Na+ channels. Scale bars, 10 µm.