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Converting Drosophobia into Drosophila

Fruit flies seek water, but only when they are thirsty. And imbibing is rewarding only to water-deprived individuals. The effects of thirst on water seeking and on formation of associative memories of drinking water each are mediated by distinct sets of dopamine neurons that innervate restricted zones of the mushroom bodies in the fly brain.

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Figure 1: Anatomically distinct dopamine inputs to restricted zones of MB mediate naive and learned water seeking in Drosophila.

Marina Corral Spence/Nature Publishing Group


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Correspondence to Josh Dubnau.

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Shih, MF., Dubnau, J. Converting Drosophobia into Drosophila. Nat Neurosci 17, 1430–1432 (2014).

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