Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Axons hooked to Schwann cell metabolism

Long axonal projections seem to be metabolically coupled to ensheathing glial cells. Targeting LKB1, a regulator of energy homeostasis, specifically in Schwann cells causes a loss of predominantly small unmyelinated fibers.

Your institute does not have access to this article

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Figure 1: Regulators of Schwann cell metabolism and axonal support.

References

  1. Lazzarini, R.A. et al. Myelin Biology and Disorders (Elsevier Publishers, 2004).

  2. Nave, K.-A. Nat. Rev. Neurosci. 11, 275–283 (2010).

    CAS  Article  Google Scholar 

  3. Beirowski, B. et al. Nat. Neurosci. 17, 1351–1361 (2014).

    CAS  Article  Google Scholar 

  4. Wedel, M.J. Acta Palaeontol. Pol. 57, 251–256 (2012).

    Article  Google Scholar 

  5. López, J.C. Nat. Rev. Neurosci. 1, 153–156 (2000).

    Article  Google Scholar 

  6. Fünfschilling, U. et al. Nature 485, 517–521 (2012).

    Article  Google Scholar 

  7. Lee, Y. et al. Nature 487, 443–448 (2012).

    CAS  Article  Google Scholar 

  8. Hardie, D.G. & Alessi, D.R. BMC Biol. 11, 36 (2013).

    Article  Google Scholar 

  9. Mei, L. & Nave, K.-A. Neuron 83, 27–49 (2014).

    CAS  Article  Google Scholar 

  10. Chen, S. et al. Nat. Neurosci. 6, 1186–1193 (2003).

    CAS  Article  Google Scholar 

  11. Zenker, J., Zieger, D. & Chrast, R. Trends Neurosci. 36, 439–449 (2013).

    CAS  Article  Google Scholar 

  12. Sugimoto, K., Murakawa, Y. & Sima, A.A.F. J. Peripher. Nerv. Syst. 7, 44–53 (2002).

    CAS  Article  Google Scholar 

  13. Véga, C. et al. J. Physiol. (Lond.) 546, 551–564 (2003).

    Article  Google Scholar 

  14. Contreras, C.M. et al. Dis. Model. Mech. 3, 181–193 (2010).

    CAS  Article  Google Scholar 

  15. Sherman, D.L. et al. J. Neurosci. 32, 1817–1825 (2012).

    CAS  Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Klaus-Armin Nave.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Tzvetanova, I., Nave, KA. Axons hooked to Schwann cell metabolism. Nat Neurosci 17, 1293–1295 (2014). https://doi.org/10.1038/nn.3825

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nn.3825

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing