Long axonal projections seem to be metabolically coupled to ensheathing glial cells. Targeting LKB1, a regulator of energy homeostasis, specifically in Schwann cells causes a loss of predominantly small unmyelinated fibers.
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Tzvetanova, I., Nave, KA. Axons hooked to Schwann cell metabolism. Nat Neurosci 17, 1293–1295 (2014). https://doi.org/10.1038/nn.3825
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DOI: https://doi.org/10.1038/nn.3825
