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Axons hooked to Schwann cell metabolism

Long axonal projections seem to be metabolically coupled to ensheathing glial cells. Targeting LKB1, a regulator of energy homeostasis, specifically in Schwann cells causes a loss of predominantly small unmyelinated fibers.

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Figure 1: Regulators of Schwann cell metabolism and axonal support.


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Correspondence to Klaus-Armin Nave.

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Tzvetanova, I., Nave, KA. Axons hooked to Schwann cell metabolism. Nat Neurosci 17, 1293–1295 (2014).

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