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CLEARance wars: PolyQ strikes back

Polyglutamine expansion in the androgen receptor, causing X-linked spinal and bulbar muscular atrophy, impairs its function as a transcriptional coactivator regulating an extensive network of proteins involved in protein clearance.

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Figure 1: The polyQ expansion mutation in the AR in SBMA interferes with the ability of AR to act as a transcriptional coactivator for TFEB in activating the CLEAR gene network.

Kim Caesar/Nature Publishing Group

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Correspondence to X William Yang or Ai Yamamoto.

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Yang, X., Yamamoto, A. CLEARance wars: PolyQ strikes back. Nat Neurosci 17, 1140–1142 (2014). https://doi.org/10.1038/nn.3793

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