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The epigenetic landscape of Alzheimer's disease

Two independent epigenome-wide association studies of Alzheimer's disease cohorts have identified overlapping methylation signals in four loci, ANK1, RPL13, RHBDF2 and CDH23, not previously associated with Alzheimer's disease. These studies also suggest that epigenetic changes contribute more to Alzheimer's disease than expected.

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Figure 1: Loci showing methylation changes with replicable effect in the two independent studies.

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Correspondence to Carlos Cruchaga.

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Lord, J., Cruchaga, C. The epigenetic landscape of Alzheimer's disease. Nat Neurosci 17, 1138–1140 (2014). https://doi.org/10.1038/nn.3792

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