Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Something wicked this way comes: huntingtin

Nature Neuroscience volume 17, pages 1014–1015 (2014)Cite this article

Subjects

Does cell-to-cell spreading of misfolded proteins occur in all neurodegenerative disorders? A study in this issue of Nature Neuroscience now demonstrates propagation of mutant huntingtin in brain slice cultures and in vivo, thereby extending the process of cell-to-cell propagation of misfolded proteins to Huntington's disease.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Potential cellular pathways for misfolded protein propagation.

References

  1. Pecho-Vrieseling et al. Nat. Neurosci. 17, 1064–1072 (2014).

    Article  CAS  Google Scholar 

  2. Pan, K.M. et al. Proc. Natl. Acad. Sci. USA 90, 10962–10966 (1993).

    Article  CAS  Google Scholar 

  3. Garden, G.A. & La Spada, A.R. Neuron 73, 886–901 (2012).

    Article  CAS  Google Scholar 

  4. Eisele, Y.S. et al. Science 330, 980–982 (2010).

    Article  CAS  Google Scholar 

  5. Luk, K.C. et al. Science 338, 949–953 (2012).

    Article  CAS  Google Scholar 

  6. Ren, P.H. et al. Nat. Cell Biol. 11, 219–225 (2009).

    Article  CAS  Google Scholar 

  7. Herrera, F. et al. PLoS Curr. 3, RRN1210 (2011).

    Article  Google Scholar 

  8. Wang, N. et al. Nat. Med. 20, 536–541 (2014).

    Article  CAS  Google Scholar 

  9. Gousset, K. et al. Nat. Cell Biol. 11, 328–336 (2009).

    Article  CAS  Google Scholar 

  10. Steiner, J.A., Angot, E. & Brundin, P. Cell Death Differ. 18, 1425–1433 (2011).

    Article  CAS  Google Scholar 

  11. Visanji, N.P., Brooks, P.L., Hazrati, L.-N. & Lang, A.E. Acta Neuropathol. Commun. 1, 2 (2013).

    Article  Google Scholar 

  12. Cicchetti, F. et al. Ann. Neurol. published online, doi:10.1002/ana.24174 (6 May 2014).

Download references

Author information

Authors and Affiliations

  1. Albert R. La Spada is in the Departments of Cellular & Molecular Medicine, Division of Biological Sciences, Neurosciences and Pediatrics, Institute for Genomic Medicine, and Sanford Consortium for Regenerative Medicine, University of California, San Diego, La Jolla, California, USA, and at Rady Children's Hospital, San Diego, California, USA.,

    Albert R La Spada

Authors
  1. Albert R La Spada
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Albert R La Spada.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

La Spada, A. Something wicked this way comes: huntingtin. Nat Neurosci 17, 1014–1015 (2014). https://doi.org/10.1038/nn.3770

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nn.3770

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing