Brief Communication | Published:

A spinal analog of memory reconsolidation enables reversal of hyperalgesia

Nature Neuroscience volume 17, pages 10431045 (2014) | Download Citation

Abstract

Hyperalgesia arising from sensitization of pain relays in the spinal dorsal horn shares many mechanistic and phenotypic parallels with memory formation. We discovered that mechanical hyperalgesia could be rendered labile and reversible in mice after reactivation of spinal pain pathways in a process analogous to memory reconsolidation. These findings reveal a previously unknown regulatory mechanism underlying hyperalgesia and demonstrate the existence of reconsolidation-like processes in a sensory system.

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Acknowledgements

We thank M. Desrochers-Couture and L.J. Martin for their assistance and advice with the behavioral assays. This work was supported by a Pfizer–Fonds de recherche Québec–Santé (FRQS) Innovation Fund Award to Y.D.K., an FRQS post-doctoral Fellowship to R.P.B., Canadian Institutes of Health Research grant MOP 12942 to Y.D.K., and the Catherine Bushnell Pain Research Fellowship from the Louise and Alan Edwards foundation to R.P.B.

Author information

Affiliations

  1. Unité de neurosciences cellulaires et moléculaire, Institut universitaire en santé mentale de Québec, Québec, Canada.

    • Robert P Bonin
    •  & Yves De Koninck
  2. Department of Psychiatry and Neuroscience, Université Laval, Québec, Canada.

    • Yves De Koninck

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Contributions

R.P.B. conducted all of the experiments and analyses. R.P.B. and Y.D.K. designed the experiments and wrote the manuscript.

Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Yves De Koninck.

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DOI

https://doi.org/10.1038/nn.3758

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