Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Wrong place, wrong time: ectopic progenitors cause cortical heterotopias

A report reveals that giant subcortical heterotopia is caused by mutation of a microtubule-associated protein, Eml1. Defects in Eml1 lead to disruption of the radial migratory scaffolding network in mice and humans.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type



Prices may be subject to local taxes which are calculated during checkout

Figure 1: Schematic diagram showing aspects of normal cortical development and the point at which development is disrupted in HeCo mice.


  1. Geschwind, D.H. & Rakic, P. Neuron 80, 633–647 (2013).

    Article  CAS  Google Scholar 

  2. Chenn, A. & Walsh, C.A. Science 297, 365–369 (2002).

    Article  CAS  Google Scholar 

  3. Siegenthaler, J.A. et al. Cell 139, 597–609 (2009).

    Article  CAS  Google Scholar 

  4. Asami, M. et al. Development 138, 5067–5078 (2011).

    Article  CAS  Google Scholar 

  5. Konno, D. et al. Nat. Cell Biol. 10, 93–101 (2008).

    Article  CAS  Google Scholar 

  6. Javaherian, A. & Kriegstein, A. Cereb. Cortex 19 (suppl. 1), i70–i77 (2009).

    Article  Google Scholar 

  7. Noctor, S.C., Martinez-Cerdeno, V. & Kriegstein, A.R. J. Comp. Neurol. 508, 28–44 (2008).

    Article  Google Scholar 

  8. Molnár, Z. & Clowry, G. Prog. Brain Res. 195, 45–70 (2012).

    Article  Google Scholar 

  9. Moon, H.M. & Wynshaw-Boris, A. Wiley Interdiscip. Rev. Dev. Biol. 2, 229–245 (2013).

    Article  CAS  Google Scholar 

  10. Barkovich, A.J., Kuzniecky, R.I., Jackson, G.D., Guerrini, R. & Dobyns, W.B. Neurology 65, 1873–1887 (2005).

    Article  CAS  Google Scholar 

  11. Kielar, M. et al. Nat. Neurosci. 17, 923–933 (2014).

    Article  CAS  Google Scholar 

  12. Croquelois, A. et al. Cereb. Cortex 19, 563–575 (2009).

    Article  Google Scholar 

  13. Novegno, F. et al. Epilepsy Res. 87, 88–94 (2009).

    Article  Google Scholar 

  14. Cappello, S. et al. Neuron 73, 911–924 (2012).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Samuel J Pleasure.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Cocas, L., Pleasure, S. Wrong place, wrong time: ectopic progenitors cause cortical heterotopias. Nat Neurosci 17, 894–895 (2014).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing