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Wrong place, wrong time: ectopic progenitors cause cortical heterotopias

A report reveals that giant subcortical heterotopia is caused by mutation of a microtubule-associated protein, Eml1. Defects in Eml1 lead to disruption of the radial migratory scaffolding network in mice and humans.

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Figure 1: Schematic diagram showing aspects of normal cortical development and the point at which development is disrupted in HeCo mice.

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Correspondence to Samuel J Pleasure.

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Cocas, L., Pleasure, S. Wrong place, wrong time: ectopic progenitors cause cortical heterotopias. Nat Neurosci 17, 894–895 (2014). https://doi.org/10.1038/nn.3747

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