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Impaired import: how huntingtin harms

Nature Neuroscience volume 17, pages 747–749 (2014)Cite this article

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We now learn that mutant huntingtin binds to a complex that imports constituent proteins across the mitochondrial inner membrane, halting bioenergetics in synaptic mitochondria and predisposing to neuronal dysfunction and death.

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Figure 1: Mutant huntingtin inhibits mitochondrial protein import.

Marina Corral Spence/Nature Publishing Group

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Authors and Affiliations

  1. Elizabeth A. Jonas is in the Departments of Internal Medicine and Neurobiology, Yale University, New Haven, Connecticut, USA.,

    Elizabeth A Jonas

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  1. Elizabeth A Jonas
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Correspondence to Elizabeth A Jonas.

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Jonas, E. Impaired import: how huntingtin harms. Nat Neurosci 17, 747–749 (2014). https://doi.org/10.1038/nn.3726

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